首页 蛋白库 基因库 产品 会员服务
位置：首页 > 产品库 > Naspm trihydrochloride
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Naspm trihydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Naspm trihydrochloride图片
CAS NO:1049731-36-3
包装:10mg
市场价:1215元

Naspm trihydrochloride (1-Naphthylacetylspermine trihydrochloride) 是 Joro 蜘蛛毒素的合成类似物，是一种钙渗透性 AMPA (CP-AMPA) 受体拮抗剂。
Cas No.1049731-36-3
别名N-[3-[[4-[(3-氨基丙基)氨基]丁基]氨基]丙基]-1-萘乙酰胺三盐酸盐,1-Naphthylacetyl spermine trihydrochloride
化学名N-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-2-(naphthalen-1-yl)acetamide trihydrochloride
Canonical SMILESO=C(CC1=CC=CC2=CC=CC=C12)NCCCNCCCCNCCCN.Cl.Cl.Cl
分子式C22H34N4O.3HCl
分子量479.91
溶解度DMSO: 1.7 mg/mL,PBS (pH 7.2): 10 mg/mL
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

NASPM selectively suppresses the inwardly rectifying and Ca2+-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC50 value of 0.33 μM. The blocking effect of NASPM on the Ca2+-permeable AMPA receptors is use and voltage-dependent[1].

References:
[1]. Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36.

 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2026