Anhydroerythromycin A

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CAS NO:

23893-13-2

脱水红霉素

Anhydroerythromycin A 是大环内酯类抗生素红霉素的降解产物。Anhydroerythromycin A 是红霉素在体内外酸性水溶液中降解形成的。Anhydroerythromycin A 在体外对金黄色葡萄球菌和蜡样芽胞杆菌具有活性 (MIC 分别为12.5 和 6.25 μg/ml)。Anhydroerythromycin A 也抑制人肝微粒体中与细胞色素 P450 (CYP) 亚型 CYP3A 相关的类固醇 6β-羟化酶的活性。

生物活性

Anhydroerythromycin A is a degradation product of the macrolideantibioticerythromycin. Anhydroerythromycin A is formed via degradation of erythromycin in acidic aqueous solutions in vitro as well as in vivo. Anhydroerythromycin A is active against S. aureus and B. cereus in vitro (MICs = 12.5 and 6.25 μg/ml, respectively). Anhydroerythromycin A also inhibits steroid 6β-hydroxylase activity associated with thecytochrome P450(CYP) isoform CYP3A in human liver microsomes.

IC₅₀& Target

Macrolide

分子量

715.91

Formula

C₃₇H₆₅NO₁₂

CAS 号

23893-13-2

中文名称

红霉素EP杂质D (Anhydroerythromycin A)

结构分类

Antibiotics
Macrolide Antibiotics

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.