Dicloxacillin Sodium hydrate

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CAS NO:

13412-64-1

双氯西林钠水合物
Dicloxacillin sodium salt monohydrate

Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) 是青霉素类的窄谱β内酰胺抗生素, 可用于革兰氏阳性菌感染的研究, 有效对抗β-内酰胺酶产生的微生物如金黄色葡萄球菌。

生物活性

Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) is a narrow-spectrum β-Lactamantibioticof the penicillin class, is used to treat infections caused by susceptible Gram-positive bacteria, active against beta-lactamase-producing organisms such as Staphylococcus aureus^[1]^[2]^[3].

IC₅₀& Target

β-lactam

体外研究
(In Vitro)

Dicloxacillin exhibits EC₅₀values of 0.06 and 0.50 mg/L in ATCC 25923 and E19977, respectively. Dicloxacillin exhibits MIC values of 0.125 and 0.5 mg/L in ATCC 25923 and E19977 with pH 7.4, respectively^[3].

Cell Viability Assay^[3]

Cell Line:	Strains ATCC 25923 and E19977.
Concentration:	0-500 mg/L.
Incubation Time:	Up to 24 h.
Result:	Exhibited EC₅₀values of 0.06 and 0.50 mg/L in ATCC 25923 and E19977, respectively.

体内研究
(In Vivo)

Dicloxacillin exhibits therapeutic activity in murine peritonitis-sepsis model and all the mice are survivied^[4].

Animal Model:	Female outbred Swiss Webster mice (Murine peritonitis-sepsis model)^[4].
Dosage:	125 mg/kg.
Administration:	IV injection, single doses.
Result:	All the mice survived.

Clinical Trial

分子量

510.32

性状

Solid

Formula

C₁₉H₁₈Cl₂N₃NaO₆S

CAS 号

13412-64-1

中文名称

双氯西林钠水合物；双氯青霉素钠盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 25 mg/mL(48.99 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.9596 mL	9.7978 mL	19.5955 mL
5 mM	0.3919 mL	1.9596 mL	3.9191 mL
10 mM	0.1960 mL	0.9798 mL	1.9596 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： PBS
Solubility: 25 mg/mL (48.99 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。