Alafosfalin

立即咨询

Alafosfalin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

60668-24-8

Alafosfalin 是一种细胞壁生物合成抑制剂。Alafosfalin 是一种磷酸二肽，具有抗菌 (antibacterial) 特性。

生物活性

Alafosfalin is an inhibitor of cell wall biosynthesis. Alafosfalin is a phosphonodipeptide withantibacterialproperties^[1].

IC₅₀& Target

β-lactam

体外研究
(In Vitro)

Alafosfalin is highly active againstEscherichia coliand moderately active againstSerratia,Klebsiella,Enterobacter, andCitrobacter, but less active against gram-positive organisms than were beta-lactams such as cephazolin or ampicillin and inactive against indole-positiveProteus,Pseudomonas, andAcinetobacter^[1].

体内研究
(In Vivo)

After s.c. administration to rats, Alafosfalin is rapidly absorbed with half-lives (t_1/2) of approximately 20 minutes^[2].

Animal Model:	Pairs of male SpragueDawley rats (250 to 350 g)^[2]
Dosage:	20, 100, and 500 mg/ kg (single doses) or 800 mg/kg per day for 14 days (Pharmacokinetic Analysis)
Administration:	Administrated by s.c.
Result:	Rapidly absorbed; peak concentrations were found within 20 minutes of dosing with half-lives of approximately 20 minutes.

分子量

196.14

Formula

C₅H₁₃N₂O₄P

CAS 号

60668-24-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.