KB-5246 is a tetracyclicquinoloneand displays antibacterial activities.

KB-5246 is a tetracyclic quinolone and displays antibacterial activities. The MICs for 90% of isolates tested (MIC90s) of KB-5246 against gram-positive microorganisms such asStaphylococcus aureus, including methicillin-resistant S.aureus,Staphylococcus epidermidis,Streptococcus pneumoniae, andStreptococcus pyogenes, are 0.39 μg/mL. KB5246 inhibits 90% of isolates ofEscherichia coli,Klebsiella pneumoniae,Klebsiella oxytocaat a concentration of 0.10 μg/mL or less. When a concentration of KB-5246 at the MIC or higher is added, no regrowth after 24 h of incubation is observed^[1].

The 50% effective dose values of KB-5246 against S.pneumoniae2132 infections are 50.5 mg/kg of body weight. The activities of KB-5246 against S.aureusSmith, P.aeruginosaGN11189, andSerratia marcescensGN7577 infections are comparable to those of ofloxacin and greater than those of norfloxacin^[1].

425.86

C₁₈H₁₇ClFN₃O₄S

119474-55-4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.