Fluticasone

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Fluticasone

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

90566-53-3

氟替卡松

Fluticasone 是一种用于呼吸道研究的吸入性皮质类固醇。Fluticasone 是一种Smo激动剂，IC₅₀为 99 nM，可激活Hedgehog信号通路并促进初生神经干细胞或前体细胞的增殖。

生物活性

Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is aSmoagonist with anIC₅₀value of 99 nM. Fluticasone activatesHedgehogsignaling and promotes the proliferation of primary neuronal stem or precursor cells^[1]^[2].

体外研究
(In Vitro)

Fluticasone (0-10 μM, 2 h) inhibits U2OS cells growth with an EC₅₀value of 99 nM^[2].
Fluticasone (10-1000 nM, 48 h) decreases HRV-induced mucin production and involves in modulation of SPDEF-regulated genes and extracellular ATP release^[3].

体内研究
(In Vivo)

Fluticasone (1 mg/kg; intranasal dropping; 7 d) suppresses rhinovirus-induced airways inflammation in vivo but also impairs anti-viral immune responses and increases viral titres, leading to mucus hypersecretion^[4].

Animal Model:	C57BL/6 mice^[4]
Dosage:	1 mg/kg
Administration:	Intranasal dropping; 1 h before infection with rhinovirus 1B; 7 days
Result:	Suppressed BAL neutrophil numbers and inhibited rhinovirus-induced airway inflammation.

Clinical Trial

分子量

444.51

Formula

C₂₂H₂₇F₃O₄S

CAS 号

90566-53-3

中文名称

氟替卡松

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.