Azvudine

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Azvudine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1011529-10-4

RO-0622
FNC

Azvudine (RO-0622) 是一种有效的核苷逆转录酶抑制剂(NRTI)，对HIV、HBV和HCV具有抗病毒活性。Azvudine 对 HIV-1 (EC₅₀s 范围为0.03~6.92 nM) 和 HIV-2（EC₅₀s 范围为 0.018~0.025 nM) 有很强的抑制作用。Azvudine 抑制 NRTI 耐药病毒株。

生物活性

Azvudine (RO-0622) is a potentnucleosidereverse transcriptaseinhibitor (NRTI), with antiviral activity onHIV,HBVandHCV. Azvudine exerts highly potent inhibition onHIV-1(EC₅₀s ranging from 0.03 to 6.92 nM) andHIV-2(EC₅₀s ranging from 0.018 to 0.025 nM). Azvudine inhibits NRTI-resistant viral strains^[1].

IC₅₀& Target^[1]

HIV-1

0.03-6.92 nM (EC₅₀)

HIV-2

0.018-0.02 nM (EC₅₀)

体外研究
(In Vitro)

Azvudine (RO-0622) displays strong inhibition on wild-type HIV-1_IIIBand HIV-1_RFwith an EC₅₀ranging from 30 to 110 pM. The EC₅₀values of Azvudine against HIV-1_KM018, HIV-1_TC-1and HIV-1_{WAN T69N}are 6.92, 0.34 and 0.45 nM, respectively. Azvudine is sensitive to NRTIs-resistant strain HIV-1_74V, PIs-resistant strains HIV-1_{L10R/M46I/L63P/V82T/I84V}and HIV-1_{RF V82F/184V}, and FIs-resistant strain pNL4-3_{gp41 (36G) V38A/N42T}. The EC₅₀values of Azvudine against these resistant strains are 0.11, 0.14, 0.37 and 0.36 nM respectively^[1].

Clinical Trial

分子量

286.22

Formula

C₉H₁₁FN₆O₄

CAS 号

1011529-10-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.