ddATP

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ddATP

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CAS NO:

24027-80-3

2',3'-Dideoxyadenosine 5'-triphosphate

ddATP (2',3'-Dideoxyadenosine 5'-triphosphate)，一种 2',3'-二脱氧肌苷的活性代谢物，是 DNA 聚合酶 (DNA polymerase) 的链延长抑制剂。ddATP 可用于 Sanger 法进行 DNA 测序，以及病毒感染相关的研究。

生物活性

ddATP (2',3'-Dideoxyadenosine 5'-triphosphate), an active metabolite of 2',3'-dideoxyinosine, is a chain-elongating inhibitor ofDNA polymerase. ddATP can be used for Sanger method for DNA sequencing and research of virusinfection^[1]^[2]^[4].

体外研究
(In Vitro)

ddATP (0.05-50 μM, 30 min) inhibits adenovirus DNA synthesis in isolated nuclei from adenovirus-infected KB cells^[1].
ddATP (100 μM, 5 h) reduces the number of γH2A.X foci in the DSB (DNA double-strand breaks) oocytes^[3].
ddATP inhibits HIV replication by inhibiting HIV reverse transcriptase^[5].

Immunofluorescence^[3]

Cell Line:	DSB oocytes
Concentration:	100 μM
Incubation Time:	5 h
Result:	Suppressed the mtDNA replication without fully suppressed the nuclear DNA replication.

分子量

475.18

Formula

C₁₀H₁₆N₅O₁₁P₃

CAS 号

24027-80-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.