(Rac)-Shikonin (Shikonin) possesses anti-tumor activity. (Rac)-Shikonin (Shikonin) circumventscancer drug resistanceby induction of a necroptotic death^[1][2].

Shikonin shows a similar potency toward drug-sensitive cancer cell lines (MCF-7 and HEK293) and their drug-resistant lines overexpressing P-glycoprotein, Bcl-2, or Bcl-xL, which account for most of the clinical cancer drug resistance^[2].

288.30

C₁₆H₁₆O₅

54952-43-1

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Room temperature in continental US; may vary elsewhere.

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