ML303

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ML303

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1638211-04-7

ML303 是一种吡唑并吡啶类化合物，是流感病毒非结构蛋白 1 (NS1)的拮抗剂 (IC₉₀为 155 nM)，其对流感病毒H1N1亚型的EC₅₀值为0.7 μM。

生物活性

ML303 is a pyrazolopyridineinfluenza virusnonstructural protein 1 (NS1)antagonist (IC₉₀= 155 nM), with anEC₅₀of 0.7 μM for Influenza A virus H1N1^[1].

IC₅₀& Target

EC50: 0.7 μM (H1N1)^[1].

体外研究
(In Vitro)

ML303 (20 μM, 6 h) treatment restore IFN-β mRNA levels in MDCK cells^[1].

Western Blot Analysis^[1]

Cell Line:	MDCK cells infected with A/PR/8/34, at a MOI of 2, for 6 hours.
Concentration:	20 μM.
Incubation Time:	6 hours.
Result:	Restored IFN-β mRNA levels in MDCK cells.

分子量

399.37

性状

Solid

Formula

C₂₁H₁₆F₃N₃O₂

CAS 号

1638211-04-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month