Halofantrine hydrochloride (SKF-102886) (SKF-102886) 是一种延迟整流钾电流的阻滞剂，通过抑制人类-ether-a-go-go-related gene (HERG) 通道和一种有效的抗疟化合物。
| Cas No. | 36167-63-2 |
| 别名 | 盐酸卤泛群,SKF-102886; WR-171669 hydrochloride |
| Canonical SMILES | OC(CCN(CCCC)CCCC)C1=CC2=C(Cl)C=C(Cl)C=C2C3=CC(C(F)(F)F)=CC=C31.[H]Cl |
| 分子式 | C26H31Cl3F3NO |
| 分子量 | 536.88 |
| 溶解度 | DMSO: 30 mg/mL (55.88 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Halofantrine hydrochloride (SKF-102886) is a blocker of delayed rectifier potassium current via the inhibition of human-ether-a-go-go-related gene (HERG) channel and a potent antimalarial compound[1][2]. [1]. Krishna S, et al. Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria. Br J Clin Pharmacol. 1993 Dec;36(6):585-91. [2]. Tie, H., et al., Inhibition of HERG potassium channels by the antimalarial agent halofantrine. Br. J. Pharmacol. 130, 1967-1975, (2000) Traebert. |
