Pendulone is a isoflavanquinone with good antiplasmodial activity with anIC₅₀of 7.0 μM. Pendulone also has antileishmanial, antibacterial and anticancer activity^[1][2].

Pendulone displays moderate antiproliferative activity against the A2780 human ovarian cancer cell line, with an IC₅₀value 19.6 μM^[1].
Pendulone displays an IC₅₀value of 0.43 μg/mL, against L. donovani promastigotes. Pendulone also displays antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus (each IC₅₀of 1.44 μg/mL)^[2].
Pendulone exhibits moderate anticancer activity against human cancer cell lines (SK-MEL, KB, BT-549 and SK-OV-3) with IC₅₀values of 5.5 and 10.5 μg/mL. Pendulone also shows moderate cytotoxicities against monkey kidney fibroblasts (VERO) and pig kidney epithelial cells (LLC-PK11)^[2].
Pendulone shows strong inhibition on the effect of the cell cycle induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in Raji cells^[3].

Pendulone shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test of mouse skin using 7,12-dimethylbenz[a]-anthracene and TPA^[3].

316.31

C₁₇H₁₆O₆

69359-09-7

垂崖豆藤异黄烷醌

• Quinones
• Benzene Quinones

• Phenols
• Monophenols

• Plants
• other families

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.