Diphenidol HCl (Difenidol hydrochloride) 是一种非选择性毒蕈碱 M1-M4 受体拮抗剂，具有抗心律失常活性。
| Cas No. | 3254-89-5 |
| 别名 | 盐酸地芬尼多; Difenidol hydrochloride |
| 化学名 | 1,1-diphenyl-4-(piperidin-1-yl)butan-1-ol hydrochloride |
| Canonical SMILES | OC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCCCC3.Cl |
| 分子式 | C21H28ClNO |
| 分子量 | 345.91 |
| 溶解度 | ≥ 17.05mg/mL in DMSO |
| 储存条件 | Desiccate at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Diphenidol hydrochloride is a muscarinic antagonist employed as an antiemetic and as an antivertigo agent. References:
[1]. Leung YM, et al. Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol. Pharmacol Rep. 2012;64(3):739-44.
[2]. Leung YM, et al. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun;58(7):1147-52.
[3]. Andersson M, et al. Muscarinic receptor subtypes involved in urothelium-derived relaxatory effects in the inflamed rat urinary bladder. Auton Neurosci. 2012 Sep 25;170(1-2):5-11. |
