Homobutein

立即咨询

Homobutein

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

34000-39-0

Homobutein 是一种天然查尔酮 (可存在于许多药用植物、水果、蔬菜、香料和坚果中) 和有效的 HDACs/NF-κB 双重抑制剂，其IC₅₀值分别为 190 和 38 μM。Homobutein 也是一种铁离子 (II 和 III) 螯合剂，具各种活性，包括抗癌，抗炎，抗寄生虫和抗氧化活性。

生物活性

Homobutein a naturalchalcones(can be found in many medicinalplants, fruits, vegetables, spices and nuts), is a potentHDACs/NF-κBdual inhibitor withIC₅₀s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation^[1]^[2]^[3]^[4].

IC₅₀& Target

Toxoplasma

体外研究
(In Vitro)

Homobutein (compound 15) (20, 24, 28, 32, 40 μM; 2 h) inhibits the viability of K562 cells^[1].
Homobutein (2 h) inhibits TNFα-induced NF-κB activity in K562 cells^[1].
Homobutein (1 μg/mL; 72 h) inhibits the growth ofToxoplasma gondiiby 19.48%^[2].
Homobutein (24 h) againsts W2 and D6 strains ofP.falciparumwith IC₅₀s of 15.0 and 16.1 μM, respectively^[3].

Cell Viability Assay^[1]

Cell Line:	K562 cells
Concentration:	20, 24, 28, 32, 40 μM
Incubation Time:	2 h
Result:	Showed inhibition of viability in K562 cells.

Cell Viability Assay^[2]

Cell Line:	Toxoplasma gondiiRH-2F strain
Concentration:	1 μg/mL
Incubation Time:	72 h
Result:	Surpressed 19.48% of theToxoplasma gondii.

分子量

286.28

Formula

C₁₆H₁₄O₅

CAS 号

34000-39-0

结构分类

Flavonoids
Chalcones

Phenols
Polyphenols

来源

Plants
Compositae
Wedelia asperrima(Gardner) B.L.Turner

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.