Pentamidine-d4 (MP-601205-d4) dihydrochloride is the deuterium labeled Pentamidine dihydrochloride. Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibitsparasiteLeishmaniainfantumwith anIC₅₀of 2.5 μM. Pentamidine dihydrochloride is a potent and selectiveprotein tyrosine phosphatases(PTPases)andphosphataseof regenerating liver (PRL)inhibitor. Pentamidine dihydrochloride has the potential forGambian trypanosomiasis, antimony-resistantleishmaniasis, andPneumocystis cariniipneumonia treatment. Antitumor and antibacterial activities^[1][2][3][4].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

417.37

C₁₉H₂₂D₄Cl₂N₄O₂

1276197-32-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.