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α-GalCer analog 8
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
α-GalCer analog 8图片
CAS NO:922727-14-8
包装与价格：
包装价格(元)
500μg询价
1mg询价

Cas No.922727-14-8
别名α-Galactosylceramide analog 8
化学名(2S,3S,4R)-3,4-dihydroxy-2-(4-tetracosyl-1H-1,2,3-triazol-1-yl)octadecyl, α-D-galactopyranoside
Canonical SMILESO[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@]([C@H](O)[C@H](O)CCCCCCCCCCCCCC)([H])N2N=NC(CCCCCCCCCCCCCCCCCCCCCCCC)=C2
分子式C50H97N3O8
分子量868.3
溶解度Soluble in DMSO, Soluble in DMF, Soluble in Ethanol, Soluble in Methanol
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

α-Galactosylceramide analog 8 (α-GalCer analog 8) is a triazole derivative of α-galactosylceramide. [1] It increases IL-2 secretion by DN32.D3 NKT hybridoma cells when co-cultured with CD1d-transfected RBL cells pre-loaded with α-GalCer analog 8 at a concentration of 32 ng/ml. α-GalCer analog 8 (32 ng/ml) induces IL-4 secretion to a greater extent than the synthetic α-GalCer KRN 7000 in mouse splenocytes in vitro and in mouse serum following administration of a 1 &#181g per animal dose, indicating a Th2 response.

Reference:
[1]. Lee, T., Cho, M., Ko, S.-Y., et al. Synthesis and evaluation of 1,2,3-triazole containing analogues of the immunostimulant α-GalCer. J. Med. Chem. 50(3), 585-589 (2007).

 
 
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