Nepodin

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Nepodin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

3785-24-8

Musizin

Nepodin (Musizin) 是一种醌氧化还原酶 (PfNDH2) 抑制剂，从Rumex crispus中分离。Nepodin (Musizin) 通过激活 AMPK 刺激 GLUT4 向质膜的转运。Nepodin (Musizin) 具有抗糖尿病和抗疟疾的作用。

生物活性

Nepodin (Musizin) is aquinone oxidoreductase (PfNDH2)inhibitor isolate fromRumex crispus^[1].Nepodin (Musizin) stimulates the translocation ofGLUT4to the plasma membrane by activation ofAMPK^[2].Nepodin (Musizin) has antidiabetic and antimalarial activities.

IC₅₀& Target

Plasmodium

体外研究
(In Vitro)

Nepodin (Musizin) exhibits significant IC₅₀values that are 0.74 and 0.79 μg/ml againstP. falciparumchloroquine-sensitive (3D7) andP. falciparumchloroquine-resistant (S20), respectively^[1].

体内研究
(In Vivo)

Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner^[2].

Animal Model:	C57BL/KsJ-db/db mice^[2]
Dosage:	2 mg/kg; 10 mg/kg
Administration:	Orally administration; 2-10 mg/kg; 4 weeks
Result:	Had antihyperglycemic potential and improved insulin resistance.

分子量

216.23

性状

Solid

Formula

C₁₃H₁₂O₃

CAS 号

3785-24-8

结构分类

Phenols
Polyphenols

来源

Plants
Polygonaceae
Rumex japonicusHoutt.

Plants
Polygonaceae
Rumex crispusLinn.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 125 mg/mL(578.09 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	4.6247 mL	23.1235 mL	46.2471 mL
5 mM	0.9249 mL	4.6247 mL	9.2494 mL
10 mM	0.4625 mL	2.3124 mL	4.6247 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。