Polyketomycin is a tetracyclic quinone glycosideantibioticisolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth ofGram-positive bacteria, and its MIC values is less than 0.2 μg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities^[1][2][3].

Polyketomycin exhibits growth inhibition against L1210 leukemia, EL-4 leukemia, P388 leukemia, Ehrlich carcinoma, IMC carcinoma, colon 26 adnocarcinoma, Meth A fibrosarcoma, FS-3 fibrosarcoma and B16-BL10 melanoma with IC₅₀values of 3.3 μg/mL, 2.1 μg/mL, 5.2 μg/mL, 1 μg/mL, 0.9 μg/mL, 1.8 μg/mL, 2.4 μg/mL, 1.5 μg/mL and 1.6 μg/mL, respectively^[1].

The acute toxicity (LD₅₀, ip) of Polyketomycin in mice is estimated to be 6.25-12.5mg/kg^[1].

864.84

C₄₄H₄₈O₁₈

200625-47-4

• Quinones
• Naphthalene Quinones

• Phenols
• Polyphenols

Streptomyces sp. MK277-AF1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.