Stavudine sodium

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Stavudine sodium

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

134624-73-0

司他夫定钠
d4T sodium

Stavudine (d4T) sodium 是一种口服活性核苷逆转录酶抑制剂 ((NRTI))。Stavudine sodium 具有抗HIV-1和HIV-2的活性。Stavudine sodium 还抑制线粒体 DNA (mtDNA) 的复制。Stavudine sodium 降低 NLRP3 炎症小体激活，调节淀粉样 β 自噬。Stavudine sodium 诱导细胞凋亡。

生物活性

Stavudine (d4T) sodium is an orally activenucleosidereverse transcriptaseinhibitor(NRTI). Stavudine sodium has activity againstHIV-1andHIV-2. Stavudine sodium also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine sodium reducesNLRP3inflammasome activation and modulatesAmyloid-βautophagy. Stavudine sodium inducesapoptosis^[1]^[2]^[3]^[4].

IC₅₀& Target

HIV-1

HIV-2

NLRP3

体外研究
(In Vitro)

Stavudine (d4T) sodium (50 μM) significantly reduces the expression of the NLRP3 inflammasome gene, IL-18 production and Aβ 42-stimulated cellular production of IL-1β in THP-1 derived macrophages^[3].
Stavudine (d4T) sodium (50 μM) inhibits the assembly of the NLRP3 inflammasome complex and down-regulates the phagocytosis of Aβ 42 by macrophages^[3].
Stavudine (d4T) sodium (10 μM, 7 or 14 days) significantly induced CEM cells apoptosis, especially after 14 days, and increases hydrogen peroxide levels^[4].

体内研究
(In Vivo)

Stavudine (d4T) sodium (500 mg/kg, daily liquid, 2 weeks) can rapidly induce fat depletion and mild liver damage at high dose in male RjOrl Swiss mice^[5].

Animal Model:	Male RjOrl Swiss mice weighing 0.028-0.03 kg^[1]
Dosage:	500 mg/kg
Administration:	Daily liquid; 2 weeks
Result:	Reduced fat weight gain by 58%, 5.7 g in the control group and 4.9 g in the d4T treated group. Significantly elevated plasma ALT and LDH levels. Reduced plasma acetoacetic acid and beta-hydroxybutyric acid levels. Reduced liver and muscle mtDNA levels at high dose concentration of 500 mg/kg.

Clinical Trial

分子量

246.20

Formula

C₁₀H₁₁N₂NaO₄

CAS 号

134624-73-0

中文名称

司他夫定钠

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.