Sphingosine (d14:1) (Tetradecasphing-4-enine) 是一种鞘脂，是一种有效的蛋白激酶 C (PKC) 抑制剂。鞘氨醇 (d14:1) 可防止其与 sn-1,2-二酰基甘油 (DAG)/佛波酯相互作用。
| Cas No. | 24558-60-9 |
| 别名 | (2S,3R,E)-2-氨基-4-十四碳烯-1,3-二醇,Tetradecasphing-4-enine |
| Canonical SMILES | OC[C@H](N)[C@H](O)/C=C/CCCCCCCCC |
| 分子式 | C14H29NO2 |
| 分子量 | 243.4 |
| 溶解度 | Chloroform: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Sphingosine (d14:1) is a bioactive sphingolipid that has been found in B. mori (silkworm), P. clarkii (crayfish), and A. aurita (jellyfish) extracts. It increases the germination rate of N. rileyi, an entomopathogenic fungus, with an EC50 value of 10.2 nM. Sphingosine (d14:1) inhibits protein kinase C (PKC) in vitro (IC50 = 7.3 mol%) as well as superoxide generation induced by phorbol 12-myristate 13-acetate in neutrophils and reduces growth of CHO cells (IC50s = 19 and 8 μM, respectively). |
