PROTAC BRD4 Degrader-9 (compound 8a) 是一种有效的由von Hippel-Lindau配体和BRD4配体相连的PROTAC。PROTAC BRD4 Degrader-9 可与 STEAP1 和 CLL1 抗体偶联从而降解 PC3 前列腺癌细胞中的 BRD4 蛋白，DC50值分别为 0.86 nM 和 7.6 nM。
| 生物活性 | PROTACBRD4 Degrader-9 (compound 8a) is aPROTACconnected by ligands forvon Hippel-LindauandBRD4.PROTACBRD4 Degrader-9 can be conjugated with STEAP1 and CLL1 antibodies to degrade theBRD4protein in PC3 prostatecancercells, with aDC50of 0.86 nM and 7.6 nM, respectively[1]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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