| CAS NO: | 432545-63-6 |
| 生物活性 | Methotrexate-d3 (Amethopterin-d3) is the deuterium labeled Methotrexate. Methotrexate (Amethopterin), anantimetaboliteandantifolateagent, inhibits the enzymedihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3]. | |||||||||
| 体外研究 (In Vitro) | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. | |||||||||
| 分子量 | 457.46 | |||||||||
| 性状 | Solid | |||||||||
| Formula | C20H19D3N8O5 | |||||||||
| CAS 号 | 432545-63-6 | |||||||||
| 中文名称 | 甲氨蝶呤 d3 | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
| 储存方式 |
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