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ML133 HCl
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
ML133 HCl图片
CAS NO:1222781-70-5
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ML133 HCl 是一种选择性 Kir2 家族通道抑制剂，其 IC50 为 1.8 μM 在 pH 7.4 和 290 nM 在 pH 8.5。
Cas No.1222781-70-5
别名(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐
化学名1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine;hydrochloride
Canonical SMILESCOC1=CC=C(C=C1)CNCC2=CC=CC3=CC=CC=C32.Cl
分子式C19H19NO.HCl
分子量313.82
溶解度≥ 15.7mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ML133 hydrochloride is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5[1].

ML133, which inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5, but exhibits little selectivity against other members of Kir2.x family channels[1].ML133 has no effect on Kir1.1 (IC50 >300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date[1].

References:
[1]. Wang HR, et al. Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. ACS Chem Biol. 2011 Aug 19;6(8):845-56.

 
 
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