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Bemegride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Bemegride图片
CAS NO:64-65-3

Bemegride (3-Ethyl-3-methylglutarimide) 是一种中枢神经系统兴奋剂和巴比妥类中毒的解毒剂。
Cas No.64-65-3
别名贝美格; 3-Ethyl-3-methylglutarimide; Bemegrid
化学名4-ethyl-4-methylpiperidine-2,6-dione
Canonical SMILESCCC1(CC(=O)NC(=O)C1)C
分子式C8H13NO2
分子量155.19
溶解度≥ 7.76mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning.target: GABAA receptor Bemegride has an antagonistic action on the GABAA receptor, suppressing both GABA- and pentobarbitone-evoked whole-cell currents to similar extents. [1] Long-term oral administration to the rat of barbitone, alone or together with the analeptics bemegride or pentylenetetrazol, show that the intensity of the withdrawal syndrome generally parallels the degree of associated CNS depression. [2]

References:
[1]. Mistry DK, et al. Actions of steroids and bemegride on the GABAA receptor of mouse spinal neurones in culture.Exp Physiol, 1990, 75(2),199-209.
[2]. Arblaster CI, et al. Studies on the development of physical dependence on barbitone in the rat and rat atrium. Farmaco Sci. 1986 Jan, 41(1), 3-22.

 
 
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