Oxybutynin chloride 是一种口服活性的竞争性 mAChR 拮抗剂，在小鼠膀胱和大脑皮层中特异性结合 [3H]NMS 的 Kis 分别为 14.3 和 5.55 nM。
| Cas No. | 1508-65-2 |
| 别名 | 盐酸奥昔布宁 |
| 化学名 | 4-(diethylamino)but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate;hydrochloride |
| Canonical SMILES | CCN(CC)CC#CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O.Cl |
| 分子式 | C22H32ClNO3 |
| 分子量 | 393.95 |
| 溶解度 | ≥ 19.7mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Oxybutynin chloride is an anticholinergic agent, which inhibits vascular Kv channels in a concentration-dependent manner, with an IC50 of 11.51 μM[1]. References:
[1]. Li H, The anticholinergic drug oxybutynin inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells. Clin Exp Pharmacol Physiol. 2019 Nov;46(11):1030-1036. |
