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Minoxidil
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Minoxidil图片
CAS NO:38304-91-5

Minoxidil (U10858) 是一种 ATP 敏感性钾 (KATP) 通道开放剂，一种有效的口服抗高血压剂和一种促进血管舒张的外周血管扩张剂，也影响头发生长。
Cas No.38304-91-5
别名米诺地尔; U10858
化学名3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine
Canonical SMILESC1CCN(CC1)C2=NC(=N)N(C(=C2)N)O
分子式C9H15N5O
分子量209.25
溶解度Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM[1][2][3].

Minoxidil (1-00 μM; 24 hours; RAMEC cells) treatment shows very low cytotoxicities in the whole area of concentrations examined (from 1 μM to 100 μM)[1].

Minoxidil (0.01 mmoL/kg body weight; intraperitoneal injection; for 3.5 hours; fisher 344 rats) treatment inhibits carrageenan-induced rat paw oedema with an inhibitory potency (49%)[1].

References:
[1]. Hadjipavlou-Litina D, et al. Synthesis and evaluation of the antioxidative potential of minoxidil-polyamine conjugates. Biochimie. 2013 Jul;95(7):1437-49. doi: 10.1016/j.biochi.2013.03.009. Epub 2013 Mar 28.
[2]. Davies GC, et al. Novel and established potassium channel openers stimulate hair growth in vitro: implications for their modes of action in hair follicles. J Invest Dermatol. 2005 Apr;124(4):686-94.
[3]. Cohen RL, et al. Direct effects of minoxidil on epidermal cells in culture. J Invest Dermatol. 1984 Jan;82(1):90-3.

 
 
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