Meclofenoxate hydrochloride 是一种二甲基乙醇胺 (DMAE) 和 4-氯苯氧乙酸 (pCPA) 的酯，已被证明可以改善记忆力，具有精神刺激作用，并提高一般认知能力。
| Cas No. | 3685-84-5 |
| 别名 | 盐酸甲氯酚酯 |
| 化学名 | 2-(dimethylamino)ethyl 2-(4-chlorophenoxy)acetate;hydrochloride |
| Canonical SMILES | CN(C)CCOC(=O)COC1=CC=C(C=C1)Cl.Cl |
| 分子式 | C12H17Cl2NO3 |
| 分子量 | 294.17 |
| 溶解度 | DMF: 20 mg/ml,DMSO: 33 mg/ml,Ethanol: 3 mg/ml,PBS (pH 7.2): 10 mg/ml |
| 储存条件 | Store at 2-8℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Meclofenoxate hydrochloride, an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA), has been shown to improve memory, have a mentally stimulating effect, and improve general cognition.IC50 value: Target: nootropicMeclofenoxate, administered in a dose of 50 mg/kg twice daily for 7 days using the maze-training method, increased the number of responses to the conditioned stimulus, when retention tests were made 24 hours and 7 days after training, whereas citicholine, applied in the same way in a dose of 10 mg/kg, shortened the latency of the responses with reinforcement during the training and increased the number of correct responses to the conditioned stimulus in retention tests 7 days after the training [1]. Meclofenoxate appears to increase the consolidation of new information into long-term memory, but does not affect other aspects of remembering [2]. References:
[1]. Mosharrof AH, et al. Effects of meclofenoxate and citicholine on learning and memory in aged rats. Acta Physiol Pharmacol Bulg. 1987;13(4):17-24.
[2]. Marcer D, et al. The differential effects of meclofenoxate on memory loss in the elderly. Age Ageing. 1977 May;6(2):123-31. |
