Propargyl-PEG2-NHBoc 是一种可降解 (cleavable) 的 ADC linker，用于抗体偶联药物 (ADCs) 的合成。Propargyl-PEG2-NHBoc 是一种 PROTAC linker，属于 PEG 类。Propargyl-PEG2-NHBoc 可用于合成一系列 PROTAC 分子。
| Cas No. | 869310-84-9 |
| 分子式 | C12H21NO4 |
| 分子量 | 243.3 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Propargyl-PEG2-NHBoc is a cleavableADC linkerused in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-basedPROTAC linkercan be used in the synthesis of PROTACs[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
