Duocarmycin SA 是一种有效的抗肿瘤抗生素，IC50为 10 pM。 Duocarmycin SA 是一种非常有效的细胞毒性剂，能够诱导双链 DNA 的序列选择性烷基化 (alkylation)。 Duocarmycin SA 表现出对体外质子辐射处理的多形性胶质母细胞瘤 (GBM) 细胞的协同细胞毒性。
| 生物活性 | Duocarmycin SA is a potent antitumorantibioticwith anIC50of 10 pM[1]. Duocarmycin SA is an extremely potentcytotoxicagent capable of inducing a sequence-selectivealkylationof duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro[2]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
