Hemiasterlin

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Hemiasterlin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

157207-90-4

(-)-Hemiasterlin
Milnamide B

Hemiasterlin ((-)-Hemiasterlin) 是一种抗有丝分裂的海洋天然产物，具有强效的抗癌作用。Hemasterlin 可用作抗体-药物偶联物 (ADC) 中的细胞毒性有效载荷 (ADC Cytotoxin)。

生物活性

Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effcts. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) inantibody-drug conjugates (ADCs)^[1].

IC₅₀& Target^[1]

Pyrrolobenzodiazepines

体外研究
(In Vitro)

Hemiasterlin is an antimitotic agent by disrupting microtubule dynamics causing mitotic arrest and cell death with low- to sub-nanomolar potencies against several cancer cell lines^[1].

分子量

526.71

Formula

C₃₀H₄₆N₄O₄

CAS 号

157207-90-4

中文名称

哈米特林

结构分类

Alkaloids
Indole Alkaloids

来源

marine sponges

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.