SC239

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SC239

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1977557-97-3

SC239 是一种可裂解的 2-氨基苯基半紫菀素药物连接剂。SC239 可作为 ADC 的药物连接剂。

生物活性

SC239 is acleavable2-aminophenyl hemiasterlin drug-linker. SC239 can be as the drug-linker for ADC^[1].

IC₅₀& Target

Cleavable

体外研究
(In Vitro)

SC239 is composed of a tubulin-targeting 3-aminophenyl hemiasterlin warhead,SC209(HY-144880), and a cleavable valine citrulline p-aminobenzyl carbamate linker functionalized with dibenzocyclooctyne (DBCO)^[1].
The SC239 drug-linker is conjugated via a cleavable valine citrulline p-aminobenzyl carbamate linker functionalized with dibenzocyclooctyne (DBCO)^[1].
SC239 conjugates exhibits better cytotoxic activity on Igrov1 cells which have lower expression levels of FolRα^[1].

分子量

1181.42

Formula

C₆₅H₈₄N₁₀O₁₁

CAS 号

1977557-97-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.