Boc-C16-COOH

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Boc-C16-COOH

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

843666-40-0

Boc-C16-COOH 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。Boc-C16-COOH 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。

生物活性

Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis ofantibody-drug conjugates (ADCs). Boc-C16-COOH is also a alkyl chain-basedPROTAClinker that can be used in the synthesis ofPROTACs^[1]

IC₅₀& Target

Non-cleavable

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

分子量

370.57

性状

Solid

Formula

C₂₂H₄₂O₄

CAS 号

843666-40-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL(269.85 mM;ultrasonic and warming and heat to 60℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.6985 mL	13.4927 mL	26.9855 mL
5 mM	0.5397 mL	2.6985 mL	5.3971 mL
10 mM	0.2699 mL	1.3493 mL	2.6985 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。