Boc-NH-PEG4-CH2CH2NH2

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

811442-84-9

Boc-NH-PEG4-CH2CH2NH2 是一种可降解 (cleavable) 的 5 单元 PEG 类 ADC linker，用于抗体偶联药物 (ADC) 的合成。Boc-NH-PEG4-CH2CH2NH2 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。

生物活性

Boc-NH-PEG4-CH2CH2NH2 acleavable5 unit PEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs). Boc-NH-PEG4-CH2CH2NH2 is also a PEG-basedPROTAClinker that can be used in the synthesis ofPROTACs^[1].

IC₅₀& Target

Cleavable

PEGs

Alkyl/ether

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

分子量

336.42

性状

Liquid

Formula

C₁₅H₃₂N₂O₆

CAS 号

811442-84-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)