N-Boc-PEG3-bromide

立即咨询

N-Boc-PEG3-bromide

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

165963-71-3

N-Boc-PEG3-bromide 是一种PROTAC连接桥，属于 PEG 类和 Alkyl/ether 类。N-Boc-PEG3-bromide 可用于合成一系列 PROTAC 分子。N-Boc-PEG3-bromide 是一种可降解 (cleavable) 的ADC连接桥，用于抗体药物结合物 (ADCs) 的合成。

生物活性

N-Boc-PEG3-bromide is a PEG/Alkyl/ether-basedPROTAClinkercan be used in the synthesis ofPROTACs. N-Boc-PEG3-bromide is acleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[1].

IC₅₀& Target

Cleavable

PEGs

Alkyl/ether

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

分子量

312.20

性状

Liquid

Formula

C₁₁H₂₂BrNO₄

CAS 号

165963-71-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month