Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine

首页蛋白库基因库产品会员服务

位置：首页 > 产品库 > Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

175724-30-8

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine 是一种可降解 (cleavable) 的 PEG 的ADC linker，可用于合成抗体偶联药物 (ADC)。Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine 也是一种PROTAC linker，属于 PEG 和 Alkyl/ether 类，可用于合成 PROTAC 分子。

生物活性

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is acleavablePEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG/Alkyl/ether-basedPROTAClinkerthat can be used in the synthesis ofPROTACs^[1].

IC₅₀& Target^[1]

PEGs

Cleavable

Alkyl/ether

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

分子量

505.64

性状

Liquid

Formula

C₂₅H₄₇NO₉

CAS 号

175724-30-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)