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tans-4-Hydroxy-D-proline methyl ester hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
tans-4-Hydroxy-D-proline methyl ester hydrochloride图片
CAS NO:481704-21-6

tans-4-Hydroxy-D-proline methyl ester hydrochloride 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。tans-4-Hydroxy-D-proline methyl ester hydrochloride 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。
生物活性

tans-4-Hydroxy-D-proline methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis ofantibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline methyl ester hydrochloride is also a alkyl chain-basedPROTAClinker that can be used in the synthesis ofPROTACs[1][2].

IC50& Target

Non-cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

分子量

181.62

性状

Solid

Formula

C6H12ClNO3

CAS 号

481704-21-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
 
 
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