Fmoc-NH-PEG6-CH2CH2COOH 是一种可降解的 ADC linker,用于抗体药物偶联物 (ADC) 合成。
生物活性 | Fmoc-NH-PEG6-CH2CH2COOH is a cleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)[1]. |
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体外研究 (In Vitro) | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Pure form | -20°C | 3 years | | 4°C | 2 years | In solvent | -80°C | 6 months | | -20°C | 1 month |
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