Amino-PEG2-C2-acid

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Amino-PEG2-C2-acid

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

791028-27-8

Amino-PEG2-C2-acid 是一种可降解 (cleavable) 的 3 单元 PEG 类的 ADC linker，用于抗体偶联药物 (ADC) 的合成。Amino-PEG2-C2-acid 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。

生物活性

Amino-PEG2-C2-acid is acleavable3 unit PEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs). Amino-PEG2-C2-acid is also a PEG-basedPROTAClinker that can be used in the synthesis ofPROTACs^[1].

IC₅₀& Target

Cleavable

PEGs

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

分子量

177.20

性状

Solid

Formula

C₇H₁₅NO₄

CAS 号

791028-27-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month