Aminooxy-PEG4-alcohol

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CAS NO:

106492-60-8

Aminooxy-PEG4-alcohol 是一种不可降解 (non-cleavable) 的含 4 个单元 PEG 的ADC linker，可用于合成抗体偶联药物 (ADC)。Aminooxy-PEG4-alcohol 也是一种PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。

生物活性

Aminooxy-PEG4-alcohol is anon-cleavable4 unit PEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[1]. Aminooxy-PEG4-alcohol is also a PEG-basedPROTAClinkerthat can be used in the synthesis ofPROTACs^[2].

IC₅₀& Target^[1]^[2]

PEGs	Non-cleavable

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

分子量

209.24

Formula

C₈H₁₉NO₅

CAS 号

106492-60-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.