NH-bis-PEG2

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NH-bis-PEG2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

54384-47-3

NH-bis-PEG2 是一种不可裂解 (non-cleavable) 的 2 单元 PEG 的ADC linker，用于抗体药物偶联物 (ADCs) 的合成。NH-bis-PEG2 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。

生物活性

NH-bis-PEG2 is anon-cleavable2 unit PEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs). NH-bis-PEG2 is also a PEG-basedPROTAClinker that can be used in the synthesis ofPROTACs.

IC₅₀& Target

Non-cleavable

PEGs

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

分子量

193.24

Formula

C₈H₁₉NO₄

CAS 号

54384-47-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.