Bis-PEG10-NHS ester

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Bis-PEG10-NHS ester

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2221949-02-4

Bis-PEG10-NHS ester 是一种PROTAC 连接桥，属于 PEG 类和 Alkyl/ether 类。Bis-PEG10-NHS ester 可用于合成一系列 PROTAC 分子。Bis-PEG10-NHS ester 是一种可降解 (cleavable) 的ADC连接桥，用于抗体药物结合物 (ADCs) 的合成。

生物活性

Bis-PEG10-NHS ester is a PEG/Alkyl/ether-basedPROTAClinkercan be used in the synthesis ofPROTACs. Bis-PEG10-NHS ester is acleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[1].

IC₅₀& Target^[1]

PEGs

Alkyl/ether

Cleavable

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

分子量

752.76

Formula

C₃₂H₅₂N₂O₁₈

CAS 号

2221949-02-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.