Amino-PEG11-OH

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Amino-PEG11-OH

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

15332-94-2

Amino-PEG11-OH 是一种不可降解 (non-cleavable) 的 11 单元 PEG 类 ADC 连接物，用于抗体偶联药物 (ADC) 的合成。Amino-PEG11-OH 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。

生物活性

Amino-PEG11-OH isnon-cleavable11 unit PEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs). Amino-PEG11-OH is also a PEG-basedPROTAClinker that can be used in the synthesis ofPROTACs^[1].

IC₅₀& Target^[1]

Non-cleavable

PEGs

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

分子量

501.61

Formula

C₂₂H₄₇NO₁₁

CAS 号

15332-94-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.