Fmoc-NH-PEG6-CH2COOH

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CAS NO:

437655-96-4

Fmoc-NH-PEG6-CH2COOH 是一种可降解的ADC linker，用于抗体药物偶联物 (ADC) 合成。Fmoc-NH-PEG6-CH2COOH 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。

生物活性

Fmoc-NH-PEG6-CH2COOH is a cleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs). Fmoc-NH-PEG6-CH2COOH is also a PEG-basedPROTAClinker that can be used in the synthesis ofPROTACs^[1].

IC₅₀& Target^[1]

Cleavable

Alkyl/ether

PEGs

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

分子量

561.62

性状

Viscous liquid

Formula

C₂₉H₃₉NO₁₀

CAS 号

437655-96-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month