D-Proline,4-hydroxy-,methyl ester hydrochloride

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CAS NO:

114676-59-4

D-Proline, 4-hydroxy-, methyl ester (hydrochloride) 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。D-Proline, 4-hydroxy-, methyl ester (hydrochloride) 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。

生物活性

D-Proline, 4-hydroxy-, methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis ofantibody-drug conjugates (ADCs). D-Proline, 4-hydroxy-, methyl ester hydrochloride is also a alkyl chain-basedPROTAClinker that can be used in the synthesis ofPROTACs^[1]^[2

IC₅₀& Target

Non-cleavable

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

分子量

181.62

性状

Solid

Formula

C₆H₁₂ClNO₃

CAS 号

114676-59-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)