Azido-PEG4-Val-Cit-PAB-OH

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2055024-64-9

Azido-PEG4-Val-Cit-PAB-OH 是一种可降解 (cleavable) 的含 4 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。Azido-PEG4-Val-Cit-PAB-OH 还是一种PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。

生物活性

Azido-PEG4-Val-Cit-PAB-OH is acleavable4 unit PEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[1]. Azido-PEG4-Val-Cit-PAB-OH is also a PEG-basedPROTAClinkerthat can be used in the synthesis ofPROTACs^[2].

IC₅₀& Target^[1]^[2]

Protease Cleavable

PEGs

Cleavable

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

分子量

652.74

性状

Solid

Formula

C₂₉H₄₈N₈O₉

CAS 号

2055024-64-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month