m-PEG4-Br

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m-PEG4-Br

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

110429-45-3

m-PEG4-Br 是可降解 (cleavable) 的ADC linker，用于合成曲妥珠单抗 (HY-P9907) 的抗体偶联药物 (ADC)。m-PEG4-Br 被置于单甲基澳瑞他汀 E (MMAE) 有效载荷的远端，以产生具有改变的亲水性，抗原结合和体外效能的 ADC。Tetraethylene glycol monotosylate 也可用作 PROTAC 的 Linker，可用于 PROTAC 的合成。

生物活性

m-PEG4-Br is acleavableADC linkerused in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab (HY-P9907). m-PEG4-Br is placed distally from the monomethylauristatinE (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency^[1]. m-PEG4-Br also can be used as aPROTAClinker that can be used in the synthesis ofPROTACs.

IC₅₀& Target^[1]

Cleavable

PEGs

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

分子量

271.15

性状

Liquid

Formula

C₉H₁₉BrO₄

CAS 号

110429-45-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month