Eicosanedioic acid

立即咨询

Eicosanedioic acid

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2424-92-2

Eicosanedioic acid 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。Eicosanedioic acid 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。

生物活性

Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis ofantibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-basedPROTAClinker that can be used in the synthesis

IC₅₀& Target

Non-cleavable

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

分子量

342.51

性状

Solid

Formula

C₂₀H₃₈O₄

CAS 号

2424-92-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month