Azide-PEG3-Tos

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Azide-PEG3-Tos

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

178685-33-1

Azide-PEG3-Tos 是一种PROTAC linker，属于 PEG 类，可用于合成PROTAC 分子。Azide-PEG3-Tos 也是一种不可降解 (non-cleavable) 的含 3 个单元 PEG 的ADC linker，可用于合成抗体偶联药物 (ADC)。

生物活性

Azide-PEG3-Tos is a PEG-basedPROTAClinkerthat can be used in the synthesis ofPROTACs^[1]. Azide-PEG3-Tos is also anon-cleavable3 unit PEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs)^[2].

IC₅₀& Target^[1]^[2]

PEGs	Non-cleavable

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[2].

分子量

329.37

性状

Liquid

Formula

C₁₃H₁₉N₃O₅S

CAS 号

178685-33-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month