Fmoc-azetidine-3-carboxylic acid is acleavableADC linker used in the synthesis ofantibody-drug conjugates (ADCs). Fmoc-azetidine-3-carboxylic acid is also a alkyl chain-basedPROTAClinker that can be used in the synthesis ofPROTACs^[1][2].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

323.35

Solid

C₁₉H₁₇NO₄

193693-64-0

Room temperature in continental US; may vary elsewhere.