Tr-PEG8-OH

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Tr-PEG8-OH

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1144113-16-5

Tr-PEG8-OH 是一种不可降解 (non-cleavable) 的含 8 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。Tr-PEG8-OH是一种 PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。

生物活性

Tr-PEG8-OH is anon-cleavable8 unit PEGADClinker used in the synthesis ofantibody-drug conjugates (ADCs). Tr-PEG8-OH is a PEG-basedPROTAClinker can be used in the synthesis ofPROTACs.

IC₅₀& Target

Non-cleavable

PEGs

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

分子量

612.75

Formula

C₃₅H₄₈O₉

CAS 号

1144113-16-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.